Phenotypic identification of amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae.

Abstract excerpt

Primary gene amplification, i.e., mutation from one gene copy to multiple gene copies per genome, is important in genomic evolution, as a means of producing anti-cancer drug resistance, and is associated with the progression of tumor malignancy. Primary amplification has not been studied in normal eukaryotic cells because amplifications are extremely rare in these cells. A system has been developed to...

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