Article
Mutagenic specificity of the base analog 6-N-hydroxylaminopurine in the LYS2 gene of yeast Saccharomyces cerevisiae.
Mutation research - 20 Feb 2001
Kulikov V V, Derkatch I L, Noskov V N, Tarunina O V, Chernoff Y O, Rogozin I B, Pavlov Y I
Abstract excerpt
We used the LYS2 gene mutational system to study mutation specificity of the base analog 6-N-hydroxylaminopurine (HAP) in yeast. We characterized phenotypes of mutations using codon-specific nonsense suppressors and the test employing inactivation of the release factor Sup35 due to overexpression and formation of prion-like derivative [PSI]. We have shown that HAP induces predominantly nonsense mutations. While...
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