Article
HIM1, a new yeast Saccharomyces cerevisiae gene playing a role in control of spontaneous and induced mutagenesis.
Mutation research - 15 Oct 2005
Kelberg Ekaterina P, Kovaltsova Svetlana V, Alekseev Sergey Yu, Fedorova Irina V, Gracheva Ludmila M, Evstukhina Tatiana A, Korolev Vladimir G
Abstract excerpt
We have identified a new Saccharomyces cerevisiae gene, HIM1, mapped on the right arm of the chromosome IV (ORF YDR317w), mutations in which led to an increase in spontaneous mutation rate and elevated the frequencies of mutations, induced by UV-light, nitrous acid, ethylmethane sulfonate and methylmethane sulfonate. At the same time, him1 mutation did not result in the increase of the sensitivity to the lethal...
Topics
- Chromosomes, Fungal
- Epistasis, Genetic
- Ethyl Methanesulfonate
- Genes, Fungal
- Methyl Methanesulfonate
- Mutagenesis
- Mutagens
- Mutation
- Nitrous Acid
- Open Reading Frames
- Physical Chromosome Mapping
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins