Article
Quantitative trait linkage analysis of the liability underlying a common oligogenic disease.
Genetic epidemiology - 1 Jan 2001
Maher B S, Vanyukov M M, Cooper M E, Neiwswanger K, Marazita M L
Abstract excerpt
We utilized pedigree discriminant and factor analytic approaches to combine multivariate phenotypic information into a single liability phenotype in the isolate and general populations. We applied two-stage relative-pair quantitative trait linkage analysis to detect genetic contributions to variation in the resulting liability phenotypes. Linkage analysis revealed several regions of suggestive linkage in both the...
Topics
- Chromosome Mapping
- Factor Analysis, Statistical
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Variation
- Genetics, Population
- Humans
- Models, Genetic
- Phenotype
- Quantitative Trait, Heritable