Linkage analysis in heterogeneous and complex traits.

Abstract excerpt

Linkage analysis is generally carried out under single-gene models, while complex traits are thought to be under the control of multiple interacting genes. Current issues related to linkage analysis for complex traits are discussed. It is argued that linkage analyses should be carried out for sub-phenotypes, in addition to classical "affected-unaffected" phenotypes. Correlations for phenotypes among family...

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