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Article

Detection and replication of linkage to a complex human disease.

Genetic epidemiology - 1 Jan 1997

Moldin S O

Abstract excerpt

Efforts to map susceptibility loci for complex human diseases frequently result in weak evidence for linkage, followed by failures to convincingly replicate. If a disease locus influences both affection status (AF) and a quantitative trait, a variant of the extreme discordant sib pair (EDSP) strategy may be used to judiciously sample families for a replication study. This approach was evaluated by conducting...

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PMID: 9433618
DOI: 10.1002/(SICI)1098-2272(1997)14:6<1023::AID-GEPI77>3.0.CO;2-K

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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