Detection and replication of linkage to a complex human disease.

doi:10.1002/(SICI)1098-2272(1997)14:6<1023::AID-GEPI77>3.0.CO;2-K

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Article

Detection and replication of linkage to a complex human disease.

Genetic epidemiology - 1 Jan 1997

Moldin S O

Abstract excerpt

Efforts to map susceptibility loci for complex human diseases frequently result in weak evidence for linkage, followed by failures to convincingly replicate. If a disease locus influences both affection status (AF) and a quantitative trait, a variant of the extreme discordant sib pair (EDSP) stra...

Topics

Chromosome Mapping
Computer Simulation
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Predisposition to Disease
Genetic Testing
Humans
Likelihood Functions
Male
Meiosis
Multivariate Analysis
Phenotype
Quantitative Trait, Heritable
Risk Factors

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