Article
Multivariate genetic analysis of an oligogenic disease.
Genetic epidemiology - 1 Jan 1995
Moldin S O, Van Eerdewegh P
Abstract excerpt
Joint multivariate segregation and linkage analysis provides a method for simultaneously analyzing data on affection status, correlated phenotypic traits, environmental risk factors, and other covariates. The power of this approach for mapping disease susceptibility loci of small effect (oligogenes) was evaluated by analyzing the GAW9 Problem 2 data set. The program REGRESS, which assumes a pleiotropy model in...
Topics
- Chromosome Mapping
- Environmental Health
- Genetic Diseases, Inborn
- Genetic Markers
- Humans
- Models, Genetic
- Multivariate Analysis
- Phenotype
- Risk Factors
- Software