Tests and estimates of allelic association in complex inheritance.

doi:10.1073/pnas.95.19.11389

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Article

Tests and estimates of allelic association in complex inheritance.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998

Morton N E, Collins A

Abstract excerpt

Family-based procedures such as the transmission disequilibrium test (TDT) were motivated by concern that sample-based methods to map disease genes by allelic association are not robust to population stratification, migration, and admixture. Other factors to consider in designing a study of allelic association are specification of gene action in a weakly parametric model, efficiency, diagnostic reliability for...

Topics

Alleles
Case-Control Studies
Chromosome Mapping
Diabetes Mellitus, Type 1
Family
Female
Genetic Diseases, Inborn
Genetic Linkage
Genetic Markers
Genetics
Humans
Male

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Identifiers

PMID: 9736746
DOI: 10.1073/pnas.95.19.11389
PMCID: PMC21652

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