Absence of somatic changes in p21 gene in non-Hodgkin's lymphoma and chronic myelogenous leukemia.

Article

Absence of somatic changes in p21 gene in non-Hodgkin's lymphoma and chronic myelogenous leukemia.

Hematologic pathology - 1 Jan 1995

Gong J Z, Zhou H, Hu Z, Schulman P, Vinceguerra V, Broome J D, Koduru P

Abstract excerpt

p21 is induced by and mediates the effects of p53 in response to DNA damage arresting the cell in G1 or G2, by inhibiting multiple cyclin-cyclin-dependent kinases (CDK) or binding to proliferating-cell nuclear antigen (PCNA), respectively. To determine whether p21 mutants occur in tumors we exami...

Topics

Base Sequence
Blast Crisis
Cyclin-Dependent Kinases
DNA, Neoplasm
Genes, Tumor Suppressor
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Lymphoma, B-Cell
Molecular Sequence Data
Mutation

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