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Article

Mutations and polymorphisms of the p21B transcript in breast cancer.

International journal of cancer - 15 Aug 2007

Knappskog Stian, Chrisanthar Ranjan, Staalesen Vidar, Børresen-Dale Anne-Lise, Gram Inger Torhild, Lillehaug Johan Richard, Lønning Per Eystein

Abstract excerpt

p21(WAF1/CIP1), transcribed from the CDKN1A locus, plays a key role executing p53-induced growth arrest. The recent discovery that an alternative transcript, p21B, induces apoptosis, suggests an additional important function of this gene. Here, we report p21 and p21B mutation status in large cohorts of breast cancers and compare distributions of p21B polymorphisms in cancer patients to healthy controls. In 521...

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Source

Identifiers

PMID: 17443496
DOI: 10.1002/ijc.22777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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