Article
Absence of WAF1 mutations in a variety of human malignancies.
Blood - 1 Dec 1994
Shiohara M, el-Deiry W S, Wada M, Nakamaki T, Takeuchi S, Yang R, Chen D L, Vogelstein B, Koeffler H P
Abstract excerpt
A newly cloned gene named wild-type p53-activated fragment 1 (WAF1; also known as p21, Pic-1, Cip-1, or SDI1) is directly regulated by p53 and can itself suppress tumor cell growth in culture. Induction of expression of WAF1 may be an important means by which cells with DNA injury arrest their growth to repair DNA or undergo apoptosis. Based on the hypothesis that mutations of this gene may play a role in...
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