Article
p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines.
Cell proliferation - 1 May 1996
Servomaa K, Kiuru A, Grénman R, Pekkola-Heino K, Pulkkinen J O, Rytömaa T
Abstract excerpt
The p53 tumour suppressor gene is activated following cellular exposure to DNA-damaging agents. The functions of wild-type p53 protein include transient blocking of cell cycle progression, direct or indirect stimulation of DNA repair machinery and triggering of apoptosis if DNA repair fails. Ther...
Topics
- Adult
- Aged
- Base Sequence
- Female
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Radiation Tolerance
- Tumor Cells, Cultured