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Article

p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines.

Cell proliferation - 1 May 1996

Servomaa K, Kiuru A, Grénman R, Pekkola-Heino K, Pulkkinen J O, Rytömaa T

Abstract excerpt

The p53 tumour suppressor gene is activated following cellular exposure to DNA-damaging agents. The functions of wild-type p53 protein include transient blocking of cell cycle progression, direct or indirect stimulation of DNA repair machinery and triggering of apoptosis if DNA repair fails. Therefore, the status of p53 protein may be critically associated with tumour cell radiosensitivity. In the present study...

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Source

Identifiers

PMID: 8782485
DOI: 10.1046/j.1365-2184.1996.01009.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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