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Article

Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma.

Oral oncology - 1 Dec 2008

Hoffmann Thomas K, Sonkoly Eniko, Hauser Ulrich, van Lierop Anke, Whiteside Theresa L, Klussmann Jens Peter, Hafner Dieter, Schuler Patrick, Friebe-Hoffmann Ulrike, Scheckenbach Kathrin, Erjala Kaisa, Grénman Reidar, Schipper Jörg, Bier Henning, Balz Vera

Abstract excerpt

Chemotherapy and/or radiotherapy are established measures in treatment protocols of head and neck squamous cell carcinoma (HNSCC). However, we still lack reliable predictive markers for the response to radio- and chemotherapy. The p53 pathway is involved in stress response and thus might influence chemo-/radiosensitivity. Using 29 HNSCC cell lines previously characterized for p53 mutations, we simultaneously...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Head and Neck Neoplasms

Share to Oncogene Proteins, Viral

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Source

Identifiers

PMID: 18487078
DOI: 10.1016/j.oraloncology.2008.02.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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