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Article

Loss of p53 gene mutation after irradiation is associated with increased aggressiveness in recurring head and neck cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1996

Gallo O, Chiarelli I, Bianchi S, Calzolari A, Simonetti L, Porfirio B

Abstract excerpt

The p53 gene plays a pivotal role in the control of a checkpoint during G1 and in the apoptotic program. It has been postulated that alterations of p53 may influence radio-sensitivity and prognosis in several malignancies. We studied the p53 gene status of 35 consecutive head and neck cancer patients who failed primary radiotherapy (RT) in preirradiated and postirradiated tumor samples using DNA single-strand...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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PMID: 9816336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of p53 gene mutation after irradiation is associated with increased aggressiveness in recurring head and neck cancer.PMID 9816336Read ↗

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