Article
Loss of p53 gene mutation after irradiation is associated with increased aggressiveness in recurring head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 1996
Gallo O, Chiarelli I, Bianchi S, Calzolari A, Simonetti L, Porfirio B
Abstract excerpt
The p53 gene plays a pivotal role in the control of a checkpoint during G1 and in the apoptotic program. It has been postulated that alterations of p53 may influence radio-sensitivity and prognosis in several malignancies. We studied the p53 gene status of 35 consecutive head and neck cancer pati...
Topics
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Mutation
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
- Polymorphism, Single-Stranded Conformational
- Survival Analysis