Effects of p53 Mutation on Tumor Radiosensitivity Estimated by Predictive Models.

Abstract excerpt

p53 gene mutations are common in various cancers and may provide insights in predicting tumor radiosensitivity. This study aimed to assess the effect of p53 mutations on radiosensitivity using the intrinsic radiosensitivity index (RSI) across publicly available cancer cohorts. Gene expression data, mutation data, and clinical information were obtained from the Cancer Genome Atlas dataset. RSI, calculated from the...

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