Article
Comparison of endogenous TP53 genomic status with clonogenicity and different modes of cell death after X irradiation.
Radiation research - 1 Jan 2004
Lu-Hesselmann Juxian, Abend Michael, van Beuningen Dirk
Abstract excerpt
Although extensive data indicate that the tumor suppressor TP53 modifies the radiation responses of human and rodent cells, the exact relationship between TP53 and radiation responsiveness remains controversial. To elucidate the relevance of endogenous TP53 genomic status to radiosensitivity in a cell-type-independent manner, different cells of 10 human tumor cell lines with different tissues of origin were...
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