Article
Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jul 2005
Takayama Tetsuji, Miyanishi Koji, Hayashi Tsuyoshi, Kukitsu Takehiro, Takanashi Kunihiro, Ishiwatari Hirotoshi, Kogawa Takahiro, Abe Tomoyuki, Niitsu Yoshiro
Abstract excerpt
Human aberrant crypt foci (ACF) were first identified as lesions consisting of large thick crypts in colonic mucosa of surgical specimens after staining with methylene blue. Previously we succeeded in identifying ACF by using magnifying endoscopy and analyzed the number, size, and dysplastic features of ACF in normal controls and patients with adenoma or cancer patients. On the basis of these analyses, we...
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