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Article

Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules.

The Journal of biological chemistry - 24 Feb 1995

Zhang Q, Tector M, Salter R D

Abstract excerpt

Proper folding of nascent polypeptides is essential for their function and is monitored by intracellular "quality control" elements. The molecular chaperone calnexin participates in this process by retaining in the endoplasmic reticulum a variety of unfolded proteins, including class I major histocompatibility complex molecules. We transfected human B cell lines with genes encoding either wild-type HLA-A2 heavy...

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Identifiers

PMID: 7876141
DOI: 10.1074/jbc.270.8.3944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules.PMID 7876141Read ↗

N-glycan-dependent quality control of the Na,K-ATPase beta(2) subunit.Semantic proximity Read ↗

Distinct patterns of folding and interactions with calnexin and calreticulin in human class I MHC proteins with altered N-glycosylation.Semantic proximity Read ↗

Lectin-deficient calnexin is capable of binding class I histocompatibility molecules in vivo and preventing their degradation.Semantic proximity Read ↗

Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.Semantic proximity Read ↗

Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.Semantic proximity Read ↗

Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.Semantic proximity Read ↗

Distinct contributions of the lectin and arm domains of calnexin to its molecular chaperone function.Semantic proximity Read ↗

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.Semantic proximity Read ↗

The polypeptide binding conformation of calreticulin facilitates its cell-surface expression under conditions of endoplasmic reticulum stress.Semantic proximity Read ↗

Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.Semantic proximity Read ↗

Invariant chain association with MHC class I: preference for HLA class I/beta 2-microglobulin heterodimers, specificity, and influence of the MHC peptide-binding groove.Semantic proximity Read ↗

Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I.Semantic proximity Read ↗

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