Class I MHC molecules: assembly and antigen presentation.

doi:10.1111/j.1600-065x.1999.tb01352.x

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Article

Class I MHC molecules: assembly and antigen presentation.

Immunological reviews - 1 Dec 1999

Solheim J C

Abstract excerpt

Several years ago, the only factor known to be necessary for the assembly and surface expression of class I MHC was beta 2m; even for beta 2m, it was unclear at what point in class I maturation its role was played. Recent experiments that employed attachment of an endoplasmic reticulum (ER) retention signal to beta 2m have shown that the point of time at which beta 2m is required is while the class I heavy chain...

Topics

Alleles
Animals
Antigen Presentation
Antiporters
Calcium-Binding Proteins
Calnexin
Calreticulin
Endoplasmic Reticulum
Histocompatibility Antigens Class I
Humans
Immunoglobulins
Macromolecular Substances
Membrane Transport Proteins
Models, Molecular
Protein Conformation
Ribonucleoproteins
beta 2-Microglobulin

Source

Open in PubMed

Identifiers

PMID: 10631933
DOI: 10.1111/j.1600-065x.1999.tb01352.x

Provenance

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