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Article

Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1998

Harris M R, Yu Y Y, Kindle C S, Hansen T H, Solheim J C

Abstract excerpt

Before peptide binding, a variety of endoplasmic reticulum (ER) proteins are associated with class I including calnexin, TAP, calreticulin, and tapasin. Although the selective functions of any one of these ER proteins have been difficult to define, individually or in combination they perform two general chaperone functions for class I. They promote assembly of the class I heterotrimeric molecule (heavy (H) chain,...

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PMID: 9605141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.PMID 9605141Read ↗

Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP.Semantic proximity Read ↗

Lectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.Semantic proximity Read ↗

Aglycosylated and phosphatidylinositol-anchored MHC class I molecules are associated with calnexin. Evidence implicating the class I-connecting peptide segment in calnexin association.Semantic proximity Read ↗

Distinct patterns of folding and interactions with calnexin and calreticulin in human class I MHC proteins with altered N-glycosylation.Semantic proximity Read ↗

Class I MHC molecules: assembly and antigen presentation.Semantic proximity Read ↗

The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingSemantic proximity Read ↗

Contrasting Functions of Calreticulin and Calnexin in Glycoprotein Folding and ER Quality ControlSemantic proximity Read ↗

Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules.Semantic proximity Read ↗

Lectin-deficient calnexin is capable of binding class I histocompatibility molecules in vivo and preventing their degradation.Semantic proximity Read ↗

Pathophysiological Roles of Calreticulin in Autoimmune DiseaseSemantic proximity Read ↗

Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Semantic proximity Read ↗

Impact of Calreticulin and Its Mutants on Endoplasmic Reticulum Function in Health and Disease.Semantic proximity Read ↗

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