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Article

Threonine 80 on HLA-B27 confers protection against lysis by a group of natural killer clones.

European journal of immunology - 1 Aug 1996

Luque I, Solana R, Galiani M D, González R, García F, López de Castro J A, Peña J

Abstract excerpt

Recognition of major histocompatibility complex (MHC) class I molecules on target cells by natural killer (NK) cells inhibits NK cell-mediated lysis. Although it is known that this inhibitory effect is regulated by MHC polymorphism, the precise structural determinants remain undefined. Based on t...

Topics

Adult
Alleles
Amino Acid Sequence
Clone Cells
Cytotoxicity, Immunologic
HLA-B27 Antigen
Humans
Killer Cells, Natural
Lymphocyte Activation
Molecular Sequence Data
Mutagenesis, Site-Directed
Threonine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8765048
DOI: 10.1002/eji.1830260845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8765048-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Threonine 80 on HLA-B27 confers protection against lysis by a group of natural killer clones.PMID 8765048Read ↗

Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.Semantic proximity Read ↗

NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.Semantic proximity Read ↗

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.Semantic proximity Read ↗

Role of binding pockets for amino-terminal peptide residues in HLA-B27 allorecognition.Semantic proximity Read ↗

Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone.Semantic proximity Read ↗

Effect of the substitution of critical residues on the allorecognition of HLA-B27.Semantic proximity Read ↗

General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.Semantic proximity Read ↗

Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.Semantic proximity Read ↗

Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2.Semantic proximity Read ↗

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.Semantic proximity Read ↗

The transmembrane sequence of human histocompatibility leukocyte antigen (HLA)-C as a determinant in inhibition of a subset of natural killer cells.Semantic proximity Read ↗

The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope.Semantic proximity Read ↗

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