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Article

Threonine 80 on HLA-B27 confers protection against lysis by a group of natural killer clones.

European journal of immunology - 1 Aug 1996

Luque I, Solana R, Galiani M D, González R, García F, López de Castro J A, Peña J

Abstract excerpt

Recognition of major histocompatibility complex (MHC) class I molecules on target cells by natural killer (NK) cells inhibits NK cell-mediated lysis. Although it is known that this inhibitory effect is regulated by MHC polymorphism, the precise structural determinants remain undefined. Based on the capacity of different HLA-C and HLA-B motifs specifically to inhibit cytotoxicity of some NK clones, three different...

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Source

Identifiers

PMID: 8765048
DOI: 10.1002/eji.1830260845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Threonine 80 on HLA-B27 confers protection against lysis by a group of natural killer clones.PMID 8765048Read ↗

Protection from lysis by natural killer cells of group 1 and 2 specificity is mediated by residue 80 in human histocompatibility leukocyte antigen C alleles and also occurs with empty major histocompatibility complex molecules.Semantic proximity Read ↗

NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine 80.Semantic proximity Read ↗

HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.Semantic proximity Read ↗

Role of binding pockets for amino-terminal peptide residues in HLA-B27 allorecognition.Semantic proximity Read ↗

Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone.Semantic proximity Read ↗

Effect of the substitution of critical residues on the allorecognition of HLA-B27.Semantic proximity Read ↗

General role of HLA class I molecules in the protection of target cells from lysis by natural killer cells: evidence that the free heavy chains of class I molecules are not sufficient to mediate the protective effect.Semantic proximity Read ↗

Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.Semantic proximity Read ↗

Class I-induced resistance to natural killing: identification of nonpermissive residues in HLA-A2.Semantic proximity Read ↗

Generation of allospecific natural killer cells by stimulation across a polymorphism of HLA-C.Semantic proximity Read ↗

The transmembrane sequence of human histocompatibility leukocyte antigen (HLA)-C as a determinant in inhibition of a subset of natural killer cells.Semantic proximity Read ↗

The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope.Semantic proximity Read ↗

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