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Article

Effect of the substitution of critical residues on the allorecognition of HLA-B27.

Clinical and experimental rheumatology - 1 Jan 2000

Ozen S, Clayberger C, Krensky A M, Benjamin R

Abstract excerpt

The three-dimensional structure of the HLA class I molecules has highlighted the importance of the "groove" formed by the helices. We used site-directed mutagenesis to construct a series of HLA-B27 mutants with different substitutions at the sites of the conserved amino acid residues of HLA-B27 subtypes, specifically residue 77 which is thought to be critical to the binding site of the molecule, and a residue at...

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PMID: 1282853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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