Role of binding pockets for amino-terminal peptide residues in HLA-B27 allorecognition.

Article

Role of binding pockets for amino-terminal peptide residues in HLA-B27 allorecognition.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 1992

Villadangos J A, Galocha B, López D, Calvo V, López de Castro J A

Abstract excerpt

The peptide binding site of HLA-B27 and other class I Ag consists of a series of pockets that bind peptide side chains. Two of these pockets interact with the amino-terminal peptide residue (pocket A) and with the highly conserved second residue (pocket B). In this study, the role of pockets A an...

Topics

Epitopes
HLA-B27 Antigen
Humans
Mutation
Structure-Activity Relationship
T-Lymphocytes, Cytotoxic

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