Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.

doi:10.1073/pnas.92.8.3536

Article

Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.

Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 1995

Vitale M, Sivori S, Pende D, Moretta L, Moretta A

Abstract excerpt

In the present study, we define a group of natural killer (NK) clones (group 0) that fails to lyse all of the normal allogeneic target cells analyzed. Their specificity for HLA class I molecules was suggested by their ability to lyse class I-negative target cells and by the fact that they could l...

Topics

Cell Death
Clone Cells
Cytotoxicity, Immunologic
Genetic Variation
HLA-C Antigens
Humans
Killer Cells, Natural
Receptors, Immunologic

Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells.

Abstract excerpt

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