Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma.

doi:10.1007/s00384-002-0449-9

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Article

Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma.

International journal of colorectal disease - 1 May 2003

Kim Jin C, Koo Kum H, Roh Seon A, Cho Yong K, Kim Hee C, Yu Chang S, Kim Ho J, Kim Jung S, Cho Moon K

Abstract excerpt

BACKGROUND AND AIMS: Somatic APC mutation, frequently associated with colorectal tumors, is implicated in the early stage of tumorigenesis. This study was performed to identify APC-related colorectal tumorigenesis in sporadic colorectal carcinomas with synchronous adenoma. MATERIALS AND METHODS: We screened the entire coding region of APC and also assessed 5q LOH, 5q MSI, and promoter hypermethylation in fresh...

Topics

Adenoma
Adult
Aged
Aged, 80 and over
Alleles
Carcinoma
Chromosomes, Human, Pair 5
Codon, Nonsense
Colorectal Neoplasms
DNA Methylation
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Frameshift Mutation

Gene Deletion

Genes, APC

Humans

Intestinal Mucosa

Loss of Heterozygosity

Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 12673484
DOI: 10.1007/s00384-002-0449-9

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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