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Article

Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma.

International journal of colorectal disease - 1 May 2003

Kim Jin C, Koo Kum H, Roh Seon A, Cho Yong K, Kim Hee C, Yu Chang S, Kim Ho J, Kim Jung S, Cho Moon K

Abstract excerpt

BACKGROUND AND AIMS: Somatic APC mutation, frequently associated with colorectal tumors, is implicated in the early stage of tumorigenesis. This study was performed to identify APC-related colorectal tumorigenesis in sporadic colorectal carcinomas with synchronous adenoma. MATERIALS AND METHODS: We screened the entire coding region of APC and also assessed 5q LOH, 5q MSI, and promoter hypermethylation in fresh...

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PMID: 12673484
DOI: 10.1007/s00384-002-0449-9

Genes

APC

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