Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.

doi:10.1093/hmg/1.4.229

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Article

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.

Human molecular genetics - 1 Jul 1992

Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y

Abstract excerpt

We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mu...

Topics

Adenoma
Adenomatous Polyposis Coli
Alleles
Base Sequence
Carcinoma
Colorectal Neoplasms
DNA Mutational Analysis
DNA, Neoplasm
Genes, APC
Heterozygote
Humans
Molecular Sequence Data

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