Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

Article

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

Cancer research - 1 Jun 1994

Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, Muraoka M, Takahashi H, Amada Y, Fukayama M

Abstract excerpt

Mutation of the adenomatous polyposis coli (APC) gene was analyzed in 500 colorectal tumors from 70 familial adenomatous polyposis (FAP) and 102 non-FAP patients and in normal tissues from 119 FAP patients, using polymerase chain reaction-single-strand conformation polymorphism and direct sequenc...

Topics

Adenoma
Amino Acid Sequence
Base Sequence
Carcinoma
Colorectal Neoplasms
Gene Deletion
Genes, APC
Humans
Molecular Sequence Data
Mutation
Point Mutation

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