Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline APC mutations are not commonly seen in children with sporadic hepatoblastoma.

Journal of pediatric gastroenterology and nutrition - 1 Nov 2008

Harvey Jj, Clark Sk, Hyer W, Hadzic N, Tomlinson Ipm, Hinds R

Abstract excerpt

Hepatoblastoma is the most common primary liver tumor in childhood and occurs more commonly in families with familial adenomatous polyposis. Germline mutations of the gene responsible for familial adenomatous polyposis--adenomatous polyposis coli (APC)--are described in patients with hepatoblastoma even without a family history. We investigated children presenting with apparently sporadic hepatoblastoma between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenomatous Polyposis Coli
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, APC

Share to Germ-Line Mutation

Share to Hepatoblastoma

Share to Infant

Share to Liver Neoplasms

Share to Prevalence

Source

Identifiers

PMID: 18955873
DOI: 10.1097/MPG.0b013e318174e808

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline APC mutations are not commonly seen in children with sporadic hepatoblastoma.PMID 18955873Read ↗

Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations?Semantic proximity Read ↗

Somatic mutations of the APC gene in sporadic hepatoblastomas.Semantic proximity Read ↗

Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations.Semantic proximity Read ↗

Hepatoblastoma in patients with molecularly proven familial adenomatous polyposis: Clinical characteristics and rationale for surveillance screeningSemantic proximity Read ↗

Germline APC mutations in hepatoblastomaSemantic proximity Read ↗

Hepatoblastoma and APC gene mutation in familial adenomatous polyposis.Semantic proximity Read ↗

Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.Semantic proximity Read ↗

APC germline hepatoblastomas demonstrate cisplatin-induced intratumor tertiary lymphoid structuresSemantic proximity Read ↗

The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds.Semantic proximity Read ↗

Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53.Semantic proximity Read ↗

Somatic mutations of beta-catenin play a crucial role in the tumorigenesis of sporadic hepatoblastoma.Semantic proximity Read ↗

APC mutations in sporadic medulloblastomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.