Article
Identification of DNA binding sites for the V-erbA oncoprotein, the viral homolog to thyroid hormone receptor alpha.
The Journal of steroid biochemistry and molecular biology - 1 Nov 1998
Harbers M, Wahlström G M, Vennström B
Abstract excerpt
The v-erbA oncogene protein, p75(gag-v-erbA), is a mutant form of the thyroid hormone receptor alpha (TR alpha) which has sustained mutations both in the ligand binding and DNA binding domains. The oncoprotein has therefore lost its ability to bind ligand, and its heterodimerization with the reti...
Topics
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- DNA Primers
- Dimerization
- HeLa Cells
- Humans
- In Vitro Techniques
- Mutation
- Oncogene Proteins v-erbA
- Polymerase Chain Reaction
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone
- Recombinant Fusion Proteins
- Retinoid X Receptors
- Transcription Factors
- Transfection