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Article

v-erbA acts on retinoic acid receptors in immature avian erythroid cells.

Journal of virology - 1 Feb 1993

Sande S, Sharif M, Chen H, Privalsky M

Abstract excerpt

The v-erbA oncogene of avian erythroblastosis virus (AEV) encodes an aberrant version of a gene for a thyroid hormone receptor (c-erbA) and functions in neoplasia by blocking erythroid differentiation and altering the growth properties of fibroblasts. The v-erbA gene has been proposed to act as a dominant negative allele, functioning by interfering with the actions of its normal cell homologs, the thyroid hormone...

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Identifiers

PMID: 8093487
DOI: 10.1128/JVI.67.2.1067-1074.1993
PMCID: PMC237462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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v-erbA acts on retinoic acid receptors in immature avian erythroid cells.PMID 8093487Read ↗

v-erbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action.Semantic proximity Read ↗

Association of v-ErbA with Smad4 disrupts TGF-beta signaling.Semantic proximity Read ↗

Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function.Semantic proximity Read ↗

Multiple mutations contribute to repression by the v-Erb A oncoprotein.Semantic proximity Read ↗

The carbonic anhydrase II gene, a gene regulated by thyroid hormone and erythropoietin, is repressed by the v-erbA oncogene in erythrocytic cells.Semantic proximity Read ↗

Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.Semantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.Semantic proximity Read ↗

Thyroid hormone receptor/and v-erbA. A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation.Semantic proximity Read ↗

Phosphorylation of the v-erbA protein is required for its function as an oncogene.Semantic proximity Read ↗

The oncoprotein P75gag-v-erbA represses thyroid hormone induced transcription only via response elements containing palindromic half-sites.Semantic proximity Read ↗

Thyroid hormone receptor-alpha inhibits retinoic acid-responsive gene expression and modulates retinoic acid-stimulated neural differentiation in mouse embryonic stem cells.Semantic proximity Read ↗

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