Article
v-erbA acts on retinoic acid receptors in immature avian erythroid cells.
Journal of virology - 1 Feb 1993
Sande S, Sharif M, Chen H, Privalsky M
Abstract excerpt
The v-erbA oncogene of avian erythroblastosis virus (AEV) encodes an aberrant version of a gene for a thyroid hormone receptor (c-erbA) and functions in neoplasia by blocking erythroid differentiation and altering the growth properties of fibroblasts. The v-erbA gene has been proposed to act as a...
Topics
- Alpharetrovirus
- Animals
- Base Sequence
- Carrier Proteins
- Cell Line, Transformed
- Chickens
- Erythroid Precursor Cells
- Gene Expression Regulation, Neoplastic
- Genes, Viral
- Genetic Variation
- Molecular Sequence Data
- Oncogene Proteins v-erbA
- RNA, Messenger
- Receptors, Retinoic Acid
- Retroviridae Proteins, Oncogenic
- Signal Transduction
- Transcription, Genetic