Article
Mutations in the envelope gene of hepatitis B virus variants co-occurring with antibody to surface antigen in sera from patients with chronic hepatitis B.
The Journal of general virology - 1 Aug 1996
Kohno H, Inoue T, Tsuda F, Okamoto H, Akahane Y
Abstract excerpt
Three clones of hepatitis B virus (HBV) DNA were propagated from sera of each of five patients with chronic hepatitis B who possessed hepatitis B surface antigen (HBsAg) and antibody to HBsAg in their serum. The clones were sequenced within the envelope gene (the preS1, preS2 regions and the S ge...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibody Specificity
- Base Sequence
- Chronic Disease
- Cloning, Molecular
- DNA, Viral
- Epitopes
- Genetic Variation
- Hepatitis B
- Hepatitis B Antibodies
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Humans
- Molecular Sequence Data
- Point Mutation
- Protein Precursors
- Viral Envelope Proteins