Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.

Journal of virology - 1 Jun 1997

Tai P C, Banik D, Lin G I, Pai S, Pai K, Lin M H, Yuoh G, Che S, Hsu S H, Chen T C, Kuo T T, Lee C S, Yang C S, Shih C

Abstract excerpt

We examined the full-length hepatitis B virus (HBV) envelope (surface antigen or HBV small surface antigen [HBsAg]) sequences of 12 different liver samples from 10 different hepatoma-containing chronic carriers. Surprisingly, novel and frequent mutations occurred predominantly at amino acids 40 and 47 of HBsAg, in addition to within a known protective B-cell epitope (so-called group a determinant of HBsAg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Amino Acid Sequence
Share to B-Lymphocytes
Share to Carcinoma, Hepatocellular
Share to Chronic Disease
Share to Liver
Share to Molecular Sequence Data
Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 9151885
DOI: 10.1128/JVI.71.6.4852-4856.1997
PMCID: PMC191713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.PMID 9151885Read ↗

Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: correlation with viral serotypes and clinical stages of liver disease.Semantic proximity Read ↗

Mutation hot spots in hepatitis B surface antigen in chronic carriers from Khoozestan province, southern of Iran.Semantic proximity Read ↗

Prevalence and significance of naturally occurring mutations in the surface and polymerase genes of hepatitis B virus.Semantic proximity Read ↗

Viral and Clinical Factors associated with Surface Gene Variants among Hepatitis B Virus CarriersSemantic proximity Read ↗

Mutations of hepatitis B virus liver disease.Semantic proximity Read ↗

Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection.Semantic proximity Read ↗

Genetic variants of hepatitis B virus and their clinical relevance.Semantic proximity Read ↗

Characterization of a novel hepatitis B virus mutant: demonstration of mutation-induced hepatitis B virus surface antigen group specific "a" determinant conformation change and its application in diagnostic assays.Semantic proximity Read ↗

Association of HBsAg mutation patterns with hepatitis B infection outcome: Asymptomatic carriers versus HCC/cirrhotic patientsSemantic proximity Read ↗

High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum.Semantic proximity Read ↗

Identification of a novel surface mutant of hepatitis B virus in a seronegative chronic liver disease patient.Semantic proximity Read ↗

Naturally occurring hepatitis B virus core gene mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics