Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.

doi:10.1128/JVI.71.6.4852-4856.1997

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Article

Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.

Journal of virology - 1 Jun 1997

Tai P C, Banik D, Lin G I, Pai S, Pai K, Lin M H, Yuoh G, Che S, Hsu S H, Chen T C, Kuo T T, Lee C S, Yang C S, Shih C

Abstract excerpt

We examined the full-length hepatitis B virus (HBV) envelope (surface antigen or HBV small surface antigen [HBsAg]) sequences of 12 different liver samples from 10 different hepatoma-containing chronic carriers. Surprisingly, novel and frequent mutations occurred predominantly at amino acids 40 a...

Topics

Adult
Aged
Amino Acid Sequence
B-Lymphocytes
Carcinoma, Hepatocellular
Chronic Disease
Epitope Mapping
Female
Hepatitis B Surface Antigens
Hepatitis B virus
Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Liver

Male

Middle Aged

Molecular Sequence Data

Mutation

Proviruses

Source

Open in PubMed Open full text

Identifiers

PMID: 9151885
DOI: 10.1128/JVI.71.6.4852-4856.1997
PMCID: PMC191713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9151885-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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