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Article

High level of genetic heterogeneity in S and P genes of genotype D hepatitis B virus.

Virology - 15 Aug 2007

De Maddalena Chiara, Giambelli Camilla, Tanzi Elisabetta, Colzani Daniela, Schiavini Monica, Milazzo Laura, Bernini Flavia, Ebranati Erika, Cargnel Antonietta, Bruno Raffaele, Galli Massimo, Zehender Gianguglielmo

Abstract excerpt

The genetic heterogeneity of hepatitis B virus (HBV) genotypes and subgenotypes was investigated by directly sequencing amplified PreS, S and P genes of HBV isolates obtained from the plasma of 99 subjects with chronic HBV infection. Genotype D showed the greatest intragenotypic and intrasubgenotypic divergence: in particular, the a determinant was mutated in 58.2% of the genotype D patients, two of whom showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17451771
DOI: 10.1016/j.virol.2007.03.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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