Article
Acute hepatitis B caused by a vaccine-escape HBV strain in vaccinated subject: sequence analysis and therapeutic strategy.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jan 2015
Luongo Monica, Critelli Rosina, Grottola Antonella, Gitto Stefano, Bernabucci Veronica, Bevini Mirco, Vecchi Chiara, Montagnani Giuliano, Villa Erica
Abstract excerpt
HBV vaccine contains the 'a' determinant region, the major immune-target of antibodies (anti-HBs). Failure of immunization may be caused by vaccine-induced or spontaneous 'a' determinant surface gene mutants. Here, we evaluate the possible lack of protection by HBV vaccine, describing the case of an acute hepatitis B diagnosed in a 55-year-old Caucasian male unpaid blood donor, vaccinated against HBV. Sequencing...
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