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Immune-Escape Mutations Are Prevalent among Patients with a Coexistence of HBsAg and Anti-HBs in a Tertiary Liver Center in the United States.

Viruses - 30 Apr 2024

Ali Mukarram Jamat, Shah Pir Ahmed, Rehman Khalil Ur, Kaur Satinder, Holzmayer Vera, Cloherty Gavin A, Kuhns Mary C, Lau Daryl T Y

Abstract excerpt

The concurrent seropositivity of HBsAg and anti-HBs has been described among patients with chronic hepatitis B (CHB), but its prevalence is variable. HBV S-gene mutations can affect the antigenicity of HBsAg. Patients with mutations in the 'α' determinant region of the S gene can develop severe HBV reactivation under immunosuppression. In this study at a tertiary liver center in the United States, we evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38793596
DOI: 10.3390/v16050713
PMCID: PMC11125813

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