Article
Low frequencies of somatic mutation in two expressed V kappa genes: unequal distribution of mutation in 5' and 3' flanking regions.
International immunology - 1 Mar 1993
Rickert R, Clarke S
Abstract excerpt
Somatic mutation of antibody variable region genes is a hallmark of secondary responses. Most often the coexpressed VH and V kappa genes of a B cell mutate at nearly equal rates. We have previously identified hybridomas from two B cell clones that exhibited > 10-fold lower frequency of mutation i...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- DNA
- Gene Expression Regulation
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Mice
- Molecular Sequence Data
- Mutation