Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation.

Blood - 1 Nov 1992

Bakkus M H, Heirman C, Van Riet I, Van Camp B, Thielemans K

Abstract excerpt

To investigate whether somatic hypermutation occurs in multiple myeloma (MM) Ig VH region genes, we have cloned and sequenced the expressed VH genes from five cases of MM. The sequences were obtained after polymerase chain reaction (PCR) on total RNA isolated from the bone marrow, using 5' VH family-specific leader and 3' C gamma- or C alpha-specific primers. MM-specific CDR3 oligonucleotides were produced to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Molecular Sequence Data

Share to Multigene Family

Share to Mutation

Share to Oligodeoxyribonucleotides

Source

Identifiers

PMID: 1421403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that multiple myeloma Ig heavy chain VDJ genes contain somatic mutations but show no intraclonal variation.PMID 1421403Read ↗

Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity.Semantic proximity Read ↗

Myeloma VL and VH Gene Sequences Reveal a Complementary Imprint of Antigen Selection in Tumor CellsSemantic proximity Read ↗

Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.Semantic proximity Read ↗

Immunoglobulin genes in multiple myeloma: expressed and non-expressed repertoires, heavy and light chain pairings and somatic mutation patterns in a series of 101 cases.Semantic proximity Read ↗

Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies.Semantic proximity Read ↗

Characterization of the immunoglobulin light chain variable region gene expressed in multiple myeloma.Semantic proximity Read ↗

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.Semantic proximity Read ↗

Identification of clonotypic IgH VDJ sequences in multiple myeloma.Semantic proximity Read ↗

Ig gene sequences in the study of clonality.Semantic proximity Read ↗

Analysis of the kappa light chain variable region in multiple myeloma.Semantic proximity Read ↗

Patterns of somatic mutations in VH genes reveal pathways of clonal transformation from MGUS to multiple myeloma.Semantic proximity Read ↗

Variable region genes of anti-HIV human monoclonal antibodies: non-restricted use of the V gene repertoire and extensive somatic mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.