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Article

Kappa deleting element as an alternative molecular target for minimal residual disease assessment by real-time quantitative PCR in patients with multiple myeloma.

European journal of haematology - 1 Oct 2012

Puig Noemí, Sarasquete María E, Alcoceba Miguel, Balanzategui Ana, Chillón María C, Sebastián Elena, Díaz Marcos G, San Miguel Jesús F, García-Sanz Ramón

Abstract excerpt

BACKGROUND AND OBJECTIVES: Minimal residual disease (MRD) assessment by PCR in multiple myeloma (MM) has several shortcomings, including the lack of a suitable target. Kappa deleting element (KDE) rearrangements occur in virtually all Ig-lambda B-cell malignancies and in 1/3 of Ig-kappa are not affected by somatic hypermutation and, as in ALL, could be used as PCR targets. METHODS: We have first investigated the...

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Identifiers

PMID: 22805350
DOI: 10.1111/ejh.12000

Genes

IGK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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