Article
Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.
Leukemia - 1 Aug 1994
Sahota S, Hamblin T, Oscier D G, Stevenson F K
Abstract excerpt
The identifiable neoplastic cell in multiple myeloma is the plasma cell, which usually synthesizes and secretes a monoclonal immunoglobulin. However, there exists the possibility that the neoplastic event has occurred in a less mature clonally-related cell, such as a B lymphocyte, prior to Ig cla...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- Bone Marrow
- Clone Cells
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Genes, Immunoglobulin
- Humans
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Multiple Myeloma
- Mutation
- Polymerase Chain Reaction