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Article

Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.

Leukemia - 1 Aug 1994

Sahota S, Hamblin T, Oscier D G, Stevenson F K

Abstract excerpt

The identifiable neoplastic cell in multiple myeloma is the plasma cell, which usually synthesizes and secretes a monoclonal immunoglobulin. However, there exists the possibility that the neoplastic event has occurred in a less mature clonally-related cell, such as a B lymphocyte, prior to Ig class switching. Since the presence of such a clonogenic cell could influence design of therapy, particularly with...

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PMID: 8057663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Assessment of the role of clonogenic B lymphocytes in the pathogenesis of multiple myeloma.PMID 8057663Read ↗

Evidence that the clonogenic cell in multiple myeloma originates from a pre-switched but somatically mutated B cell.Semantic proximity Read ↗

Circulating clonotypic B cells in multiple myeloma and monoclonal gammopathy of undetermined significanceSemantic proximity Read ↗

Cellular origin and extent of clonal involvement in multiple myeloma: genetic and phenotypic studies.Semantic proximity Read ↗

Ig gene sequences in the study of clonality.Semantic proximity Read ↗

Myeloma VL and VH Gene Sequences Reveal a Complementary Imprint of Antigen Selection in Tumor CellsSemantic proximity Read ↗

Multiple myeloma: new evidence and insights from the immunoglobulin heavy chain gene and phenotypes.Semantic proximity Read ↗

Phenotypic detection of clonotypic B cells in multiple myeloma by specific immunoglobulin ligands reveals their rarity in multiple myeloma.Semantic proximity Read ↗

Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma.Semantic proximity Read ↗

Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity.Semantic proximity Read ↗

The clonogenic precursor cell in multiple myeloma.Semantic proximity Read ↗

B cell maturation in relation to multiple myeloma.Semantic proximity Read ↗

Immunoglobulin gene rearrangements and the pathogenesis of multiple myelomaSemantic proximity Read ↗

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