Article
A dominant transcriptional silencer located 5' to the human T-cell receptor V beta 2.2 gene segment which is activated in cell lines of thymic phenotype.
Nucleic acids research - 15 Jul 1996
Dombret H, Font M P, Sigaux F
Abstract excerpt
We have identified a transcriptional regulatory sequence located 5' to the human T-cell receptor V beta 2.2 promoter. The upstream part of this sequence acts as a transcriptional activator in the three cell lines, Jurkat, MOLT4 and HSB2, which all have a thymic phenotype. The downstream part of the sequence exerts a dominant silencing activity in the Jurkat and MOLT4 cell lines, but not in the immature HSB2 cell...
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