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Article

Effects of translocations on transcription from PVT.

Molecular and cellular biology - 1 Apr 1990

Shtivelman E, Bishop J M

Abstract excerpt

We have previously described a transcription unit on human chromosome 8, designated as PVT, that is consistently disrupted by the minority forms of translocations [t(2;8) and t(8;22)] in Burkitt's lymphoma. PVT begins 57 kilobase pairs downstream of the proto-oncogene MYC and is more than 200 kilobase pairs in length. In order to explore the pathogenic impact of translocations affecting PVT, we have characterized...

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Source

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Identifiers

PMID: 2181290
DOI: 10.1128/mcb.10.4.1835-1839.1990
PMCID: PMC362296

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Effects of translocations on transcription from PVT.PMID 2181290Read ↗

Effects of translocations on transcription from PVT.Semantic proximity Read ↗

Variant translocations in sporadic Burkitt's lymphoma detected in fresh tumour material: analysis of three cases.Semantic proximity Read ↗

Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.Semantic proximity Read ↗

Expression and replication timing patterns of wildtype and translocated BCL2 genes.Semantic proximity Read ↗

The PVT‐1 oncogene is a Myc protein target that is overexpressed in transformed cellsSemantic proximity Read ↗

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.Semantic proximity Read ↗

Expression of P0- and P3-RNA from the normal and translocated c-myc allele in Burkitt's lymphoma cells.Semantic proximity Read ↗

The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.Semantic proximity Read ↗

A dominant transcriptional silencer located 5' to the human T-cell receptor V beta 2.2 gene segment which is activated in cell lines of thymic phenotype.Semantic proximity Read ↗

The intron enhancer of the immunoglobulin kappa gene activates c-myc but does not induce the Burkitt-specific promoter shift.Semantic proximity Read ↗

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