Effects of translocations on transcription from PVT.

doi:10.1128/mcb.10.4.1835-1839.1990

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Article

Effects of translocations on transcription from PVT.

Molecular and cellular biology - 1 Apr 1990

Shtivelman E, Bishop J M

Abstract excerpt

We have previously described a transcription unit on human chromosome 8, designated as PVT, that is consistently disrupted by the minority forms of translocations [t(2;8) and t(8;22)] in Burkitt's lymphoma. PVT begins 57 kilobase pairs downstream of the proto-oncogene MYC and is more than 200 kilobase pairs in length. In order to explore the pathogenic impact of translocations affecting PVT, we have characterized...

Topics

Base Sequence
Burkitt Lymphoma
Chromosome Mapping
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 8
Cloning, Molecular
Gene Library
Genetic Variation
Humans
Molecular Sequence Data
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Mas

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-myc

Proto-Oncogenes

RNA, Neoplasm

Transcription, Genetic

Translocation, Genetic

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Identifiers

PMID: 2181290
DOI: 10.1128/mcb.10.4.1835-1839.1990
PMCID: PMC362296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2181290-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Effects of translocations on transcription from PVT.PMID 2181290Read ↗

Effects of translocations on transcription from PVT.Semantic proximity Read ↗

Variant translocations in sporadic Burkitt's lymphoma detected in fresh tumour material: analysis of three cases.Semantic proximity Read ↗

Allele-specific activation of the c-myc gene in an atypical Burkitt's lymphoma carrying the t(2;8) chromosomal translocation 250 kb downstream from c-myc.Semantic proximity Read ↗

Expression and replication timing patterns of wildtype and translocated BCL2 genes.Semantic proximity Read ↗

The PVT‐1 oncogene is a Myc protein target that is overexpressed in transformed cellsSemantic proximity Read ↗

Effect of somatic mutation within translocated c-myc genes in Burkitt's lymphoma.Semantic proximity Read ↗

Expression of P0- and P3-RNA from the normal and translocated c-myc allele in Burkitt's lymphoma cells.Semantic proximity Read ↗

The block to transcription elongation is promoter dependent in normal and Burkitt's lymphoma c-myc alleles.Semantic proximity Read ↗

A dominant transcriptional silencer located 5' to the human T-cell receptor V beta 2.2 gene segment which is activated in cell lines of thymic phenotype.Semantic proximity Read ↗

The intron enhancer of the immunoglobulin kappa gene activates c-myc but does not induce the Burkitt-specific promoter shift.Semantic proximity Read ↗

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