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Article

Reversion of a transcriptionally defective MHC class II-negative human B-cell mutant.

Nucleic acids research - 11 Feb 1993

Ombra M N, Perfetto C, Autiero M, Anzisi A M, Pasquinelli R, Maffei A, Del Pozzo G, Guardiola J

Abstract excerpt

RJ2.2.5, a mutant derived from the human B-lymphoma cell, Raji, is unable to express the MHC class II genes because of a recessive transcriptional defect attributed to the lack of an activator function. We report the isolation of a RJ2.2.5 revertant, namely AR, in which the expression of the mRNAs encoded by these genes is restored. Comparison of the binding of nuclear extracts or of partially purified nuclear...

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Identifiers

PMID: 8441650
DOI: 10.1093/nar/21.3.381
PMCID: PMC309128

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