Article
The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990
Toledano M B, Roman D G, Halden N F, Lin B B, Leonard W J
Abstract excerpt
High-affinity receptors for interleukin 2 (IL-2) are expressed on T cells following activation. These receptors are composed of both alpha and beta chains. Expression of alpha chains and, therefore, expression of high-affinity receptors are critically regulated at the level of transcription initiation. We have further dissected the regulatory elements involved in controlling transcription of the IL-2 receptor...
Topics
- Base Sequence
- Cell Line
- DNA, Neoplasm
- Genes
- Humans
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Oligonucleotide Probes