Dominant negative activity of thyroid hormone receptor variant alpha2 and interaction with nuclear corepressors.

Abstract excerpt

The splicing variant of the thyroid hormone receptor alpha (TRalpha) gene, TR variant alpha2 (TRv alpha2), lacks the second half of the ninth heptad, a domain thought to be important for heterodimerization with retinoid X receptors (RXRs). In transient transfection studies, TRv alpha2 exhibits weak dominant negative inhibition of TRalpha1-mediated transcription. In contrast, a TRv alpha2 mutant in which the ninth...

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