Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells

1 Mar 1996

Abstract excerpt

To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection. Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals. As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8621390
DOI: 10.1074/jbc.271.10.5369

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T CellsPMID 8621390Read ↗

An Essential Role of the Nuclear Factor of Activated T Cells in the Regulation of the Expression of the Cyclooxygenase-2 Gene in Human T LymphocytesSemantic proximity Read ↗

Transcriptional Regulation of the Human Toll-Like Receptor 2 Gene in Monocytes and MacrophagesSemantic proximity Read ↗

Analysis of the AP-1 sites in the IL-2 promoter.Semantic proximity Read ↗

The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.Semantic proximity Read ↗

Transcriptional regulation of cyclooxygenase-2 in the human microvascular endothelial cell line, HMEC-1: control by the combinatorial actions of AP2, NF-IL-6 and CRE elements.Semantic proximity Read ↗

The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.Semantic proximity Read ↗

Transcriptional and post‐transcriptional regulation of TcR, CD4 and CD8 gene expression during activation of normal human T lymphocytes.Semantic proximity Read ↗

Transcriptional regulation of the IL-2 gene.Semantic proximity Read ↗

Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expressionSemantic proximity Read ↗

Crucial Role for Nuclear Factor of Activated T Cells in T Cell Receptor-mediated Regulation of Human Interleukin-17Semantic proximity Read ↗

Transcriptional control of the human thromboxane synthase gene in vivo and in vitro.Semantic proximity Read ↗

An AP-1 Binding Sequence Is Essential for Regulation of the Human α2(I) Collagen (COL1A2) Promoter Activity by Transforming Growth Factor-βSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.