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Article

Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-Jun.

Cancer research - 1 Jun 2004

Kielosto Mari, Nummela Pirjo, Katainen Riikka, Leaner Virna, Birrer Michael J, Hölttä Erkki

Abstract excerpt

c-Jun is an oncogenic transcription factor involved in the regulation of cell proliferation, apoptosis and transformation. We have previously reported that cell transformations induced by ornithine decarboxylase (ODC) and c-Ha-ras oncogene, commonly activated in various cancer cells, are associated with constitutively increased phosphorylation of c-Jun on Ser residues 63 and 73. In the present study, we examined...

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PMID: 15172983
DOI: 10.1158/0008-5472.CAN-3188-2

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