Article
Transformation suppressor activity of a Jun transcription factor lacking its activation domain.
Nature - 15 Aug 1991
Lloyd A, Yancheva N, Wasylyk B
Abstract excerpt
The oncoprotein c-Jun is thought to be a mediator of ras transformation as both its synthesis and activity as a transcription factor are stimulated by ras expression. But c-Jun co-operates with ras in transformation assays, suggesting that they act along different pathways (reviewed in ref. 4). H...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes, Dominant
- Genes, Tumor Suppressor
- Genes, ras
- In Vitro Techniques
- Mice
- Mice, Nude
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Structure-Activity Relationship
- Transcription Factors
- Transcription, Genetic