Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant.

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Article

Transformation by Raf and other oncogenes renders cells differentially sensitive to growth inhibition by a dominant negative c-jun mutant.

Oncogene - 1 Dec 1994

Rapp U R, Troppmair J, Beck T, Birrer M J

Abstract excerpt

In NIH3T3 cells expressing active Raf-1 protein serine/threonine kinase (PSK) c-jun expression is constitutive while c-fos expression is attenuated. This alteration prompted us to determine whether oncogene transformation would render cells differentially sensitive to growth inhibition by a domin...

Topics

3T3 Cells
Animals
Cell Division
Cell Line
Cell Transformation, Neoplastic
Genes, Dominant
Genes, jun
Mice
Mutation
Oncogene Proteins v-raf
Oncogenes
Protein-Tyrosine Kinases
Rats
Retroviridae Proteins, Oncogenic

Source

Open in PubMed

Identifiers

PMID: 7970709

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7970709-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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