Article
ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics.
Alcoholism, clinical and experimental research - 1 Dec 1995
Thomasson H R, Beard J D, Li T K
Abstract excerpt
The class I hepatic alcohol dehydrogenases (ADHs) are primarily responsible for ethanol metabolism in humans. Genetic polymorphism at the ADH2 locus results in the inheritance of isozymes of strikingly different catalytic properties. The most common ADH2 allele, ADH2*1, encodes the low K(m) isozy...
Topics
- Adult
- Alcohol Dehydrogenase
- Alcoholic Intoxication
- Alleles
- Black People
- Ethanol
- Female
- Humans
- Isoenzymes
- Male
- Metabolic Clearance Rate
- Phenotype
- Polymorphism, Genetic
- Sex Factors
- Black or African American