Article
Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population.
Human genetics - 1 Sept 2003
Mulligan Connie J, Robin Robert W, Osier Michael V, Sambuughin Nyamkhishig, Goldfarb Lev G, Kittles Rick A, Hesselbrock Diane, Goldman David, Long Jeffrey C
Abstract excerpt
Enzymes encoded by two gene families, alcohol dehydrogenase ( ADH) and aldehyde dehydrogenase ( ALDH), mediate alcohol metabolism in humans. Allelic variants have been identified that alter metabolic rates and influence risk for alcoholism. Specifically, ADH1B*47His (previously ADH2-2) and ALDH2-2 have been shown to confer protection against alcoholism, presumably through accumulation of acetaldehyde in the blood...
Topics
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Aldehyde Dehydrogenase, Mitochondrial
- Ethanol
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Genetic Variation
- Haplotypes
- Humans
- Indians, North American
- Linkage Disequilibrium